yes, Cubase 8.0.10 on the latest public build of W10 (I think it's 10049) is running without problems here.
But I can't make real-life comparisons with my Win8 installation: i would have to install all 3d party VST(i)'s on the Win10 partition in order to do that and I'm not willing to... Komplete, EZDrummer, Superior Drummer, Kontakt libraries... it would take me hours while those prerelease builds are coming in faster every time. And all my projects use at least one of those plugin's so I can't test any of my C8 projects in Win10.
So the good news so far:
- C8 installs without problems
- C8 runs without problems (without external plugins installed)
- M-Audio's ASIO drivers are functional in W10