Most USB devices shouldn't interfere with the update - USB keyboard and mouse are no-brainers, hubs too, should pose no problems. Obviously any device using the Steinberg Yamaha driver should be disconnected as already stated, I would also disconnect any devices concerned with MIDI.
Consider too, if you follow the update instructions to the letter, disconnecting everything on USB except mouse and Keyboard, your chances of success are maximized, and should the update prove unsuccessful or exhibit any errors, there are no open questions that perhaps this or that device might have caused said corruption.
...yes I think it can be easily done, just take everything down to Highway 61.Sun Point Studio Turbenthal, SwitzerlandCubase 7.5.20 - 64bit | WaveLab 8 - 64bit | PT10 | UR28M | CMC-PD/4xFD/QC/AI/CH/TP | BCF2000 | Shuttlexpress | Graphire Tablet | Cubendo Custom Keyboard | Lenovo E31 Workstation:Xeon E3-1225V2/3.2GHz; 8GB DDR3 SDRAM; 2x Intel-Flash520 SSD 180GB (C:/D:);1TB 7200rpm Sata3 (F:); DVD RW (E:); Ext. 3TB USB3 Freecom + WD 1TB; Nvidea GeForce GT 630 4GB DDR3 Video Ram AGP PCIE | Win 7 Pro 64 Bit