Open a new project. Set it up with your preferred I/O settings. Then save the project as a Template:
File/Save As Template. Give it a name.
From now on, open each new project with the new template. All your settings will be as you originally set them.
Halion 5, Wavelab 8.03
Intel Quad Q6600, 8 Gb RAM, Abit IP35-E mobo, 250 Gb SATA system drive, 500 Gb SATA media drive, 2x1 TB storage drives
UAD-2 Solo, UAD-2 Duo, Yamaha KX8, Steinberg MR816csx, CC121, Waves 9: IR-1, Vocal and Diamond Bundles, L316, iZotope Ozone 5, RX2