(I don’t wish to offer advice higher than my pay grade 
), but if you are seeing problems even when the devices are offline, I don’t think any reinstallation of the software on your computer will help… sounds to me like the devices themselves have become corrupt. Let’s hope MOTU have the way to force a firmware reinstallation.
Please keep us informed (I am on Mac here myself, but all my audio/Midi hardware is from MOTU, so this is interesting for me too 
)