As it happened I just built the same 3930 machine and it is a race horse even w/o OC.
So far I have not done any tweaking to the OS win7 sp1 and if there are no performance problems
comming up I will leave it as it is. Keeping all bits from going into sleep mode might be worth doing, though.
Smaller track count recordings I take in 1.5 ms or 3ms which is fast enough to work with a native reverb in the Nuendo channel sends. But I have done so with a i7 930 machine and the same RME card, already. When mixing it is more the needs of e.g. UADs that lets me choose 256 or even higher. That, I guess, won't change with the faster machine.
Nuendo 5.6 (6), WL6 (7), RME, UAD, PoCo, Win7 64, i7 3930K, 16 GB RAM, 30"-21:9 monitor, Intensity, Melodyne, Spectrasonics, VSL, Brainworx, Genelec 5.1, sevaW lla, LAWO, Sony DASH 3324S, 42 RUs of classic hardware & excellent acoustic studio design, ...SB user *1989 ✝2014