No sound at all in Cubase 6.5

Does other audio work? ie: Mediaplayer.
When nothing worked for me but I was pretty sure everything should work I changed the sample rate in the Windows Control Panel / Sounds and it reactivated it. Changing it back to my usual 44.1 it still worked.
Sometimes a Windows update can throw a spanner in the works. Usually you don’t know Windows is updating and whatever you’re doing at the time may interfere with it.