No sound at all in Cubase 6.5

Yes, the the Mediaplayer and all other audio works so far I know. It’s just Cubase that’s silent. I have tryed to mess around with samplerate with no success and for now, I can’t figure out some more setting to tweak. Windows update can be a problem, but I have tryed to start cubase a lot of times and it Windows update might have been active for som of that time, but not the whole time.
When I have surfed around and try to find info, I have not find anyone with exaktly the same problem. My soundcard (Mackie Oryx Satellite) is discontinued, but there is people out there that use it with Windows 7/64, and yes, I have the right driver. Maybe it’s a problem with the Firewire card or the or the driver to the Firewire card?