Hi, not sure if you’ve solved your problem yet but from your decscription, it sounds very much like one I experienced when setting up my new PC. I had the same symptoms (although I use a different audio interface)…every other program I have worked fine with it apart from Cubase 6 which refused to play or record audio. I tried using the asio4all driver which did solve it but wasn’t the best solution. I finally tracked down someone using the same interface and he kindly sent me a copy of his Port Setup file…after a couple of tweaks in VST Connections, everything was running smoothly so I’m assuning my Port Setup was corrupted somehow. Might be worth looking into if you’re still stuck 