Thanks for the reply. The files are mono and there isn’t anything else running at the same time. There’s also plenty of disk space available. In fact, even with 2 wav files imported on 2 different channels, I see the problem happening with one of them, even when playing that channel alone, it won’t work; so, it’s not load related. However, if I restart Cubase, sometimes both channels will be ok; but other times, upon restart, the file that was previously playing ok won’t play anymore and the one that wasn’t playing then will play ok. This problem is driving me crazy. Also, note that the files always play ok if I play them from the “import” window or if I play them from the channel solo editor. They just won’t play from the multi-track project window. Grrrr!