Cubase LE 5 - WAV file imported into a channel won't play

That’s what I was thinking, too. IIRC, the preferences files are carried over if you don’t manually delete them. If you want a completely clean re-installation you need to remove all traces of the previous.

Just going by (somewhat hazy) memory here. I could be wrong.

It might still be worth trying to “trash your prefs” if you haven’t yet.