I don't know if it's the same issue but I've noticed noise too , especially with my mutli-effect. I'm using an alesis io dock. The noise disapears if I close the power of the alesis dock, leaving cubasis, letting the multi effect (or your guitar cable) cable on and repower the dock and reopen cubasis. Maybe you should try that , or try the opposite (closing the multieffect and letting cubasis open at the same time).
For the 16-bit, i've made my first mixdown, transform it to aac, and i found the sound's very good, close to my old tascam cp-24, which is 24 bit.
Ipad 3, Iphone 6plus, Cubasis, Jamup pro xt, Tascam 2488, Alesis io dock, Apogee Jam, Vox Tonelab ST, Beyerdynamic DT-770 Pro, behringer b2, music Man John Petrucci 6, Music Man John Petrucci XI 7, Schecter Hellraiser 7, taylor 814 ce, H&K Switchblade 100 Head