setting up Cubase 7 with Mackie Onyx 400f

Thank you for you tip, Split.
However, even when setting buffer to 1024, it is the same noise.

just to refine the explenation a little.
It sounds like a typical buffer issue, like losing signal on the phone really… picking up the Words said, but With chopped up sound that makes it sound like noise…

maybe not very good explained, but…