Unless your DAW of choice offers Delay compensation restraining, you may indeed be SOL.
I personally use a HW based effect chain (Line 6 POD - but there are others) so the plugins use HW based effects which are external to and prior to the DAW, but this may not be a viable alternative for you.
Another possibility might be Re-Amping (or perhaps Post Processing would be a better name in this scenario). This would have you record dry and apply effect plugins afterward.
Just a couple of ideas.