Actually - this has nothing to do with the way “I” work in Nuendo - it’s that pretty much ALL Nuendo users work this way - we ALL use wav files - No mystery here.
Well- the only time I would ever care about “less” space - is when I am archiving or backing up data.
But in this day and age when 1TB of space costs less than a typical night out - my apologies - but I do not understand why anyone would purchase an expensive DAW like Nuendo and then instantly handcuff it with a low capacity SSD and a reliance on some obscure open source format just to be able to do a session?
Seems a lot easier to just get a decent drive, rock normal wav files and operate in Nuendo at full capacity with no worries.
But hey - each to their own I guess. Good luck in your quest 
VP