Hi,
Steinberg Support answered me that with the only one returned unit for this reason of noise, they did tests on multiple machines and don’t have the problem… They said that in similar cases they had seen, including other brands, the cause is usually on a specific system and caused by computer’s USB power system.
If could be an USB power issue, why some customers did the same tests with other brands USB-powered interfaces and there was absolutely no noise? Only happens with UR22… Maybe UR22 requires a best USB power than the other brands.
Have you tried on others desktop and laptops?