If you set the video delay as a latency in Device Setup, Nuendo does the right thing:
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It shoots out the picture earlier than the sound, just enough to compensate for card and pix monitor latency, so you’re watching in sync.
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But it does not apply any compensation when you’re scrubbing, jogging, shuttling, or whatever you want to call it. So you can spot or still-frame, or use edit mode (pix automatically moves along with the start of an event you’re placing) and know that your timing is accurate.
This is a lot better than manually sliding the pix on your timeline.
As far as voice-over… I haven’t tested if there’s a way to compensate VST connect for the talent’s distant monitor. I suspect not. But who cares about 250 ms latency on a voice-over? You can fix it while you’re editing, cleaning breaths, and doing other stuff. Or if you’re lazy, just dial -250 ms into the track control.