Can't save any plugin settings- any ideas?

It is quiet because it seems like a new issue that few have come across. Chewy is always awesome for helping folks around this forum. I wish I could be of some help, but I can only watch and feel for you. I have no idea what can be up.

I hope you can work this out! Did you send a ticket into Steinberg? They usually get back to me in 5 business days or so. They have been helpful to me in the past. Though some of these issues are user specific, some are also updates that are needed. Have you tried earlier versions of Nuendo?