Sadly a lot of the prefs is in just one file, the Default.xml. And that’s also often the one that crash / needs to be deleted.
To test if it is the prefs that is the culprit you can do this:
https://www.steinberg.net/en/support/knowledgebase_new/show_details/kb_show/safe-start-mode-resetting-the-cubase-preferences/kb_back/2025.html?tx_p77sbknowledgebase_pi1[keyword_search]=preferences
And here is a document describing the different files:
https://www.steinberg.net/en/support/knowledgebase_new/show_details/kb_show/cubase-and-nuendo-program-preferences-files-in-detail/kb_back/2025.html?tx_p77sbknowledgebase_pi1[keyword_search]=preferences
Don’t forget the KB guys! It is in fact getting better and better.
-Pål