Cubase Crashes, then loses ASIO, requiring reboot

Yeah, this unfortunately is the case as it keeps some processes locked for a couple minutes until they’re flushed (so restarting is usually faster). This has’t been an issue for me since I got an RME interface though as their driver seems ok with starting another asio task even right after a cubendo crash. (I’d had the same experience as you with an maudio driver.)