I wonder if it is related to a serious bug I reported a while back, but has since disappeared from the ‘issues’ forum.
1 out of 4(?) times, I get a dangerous blast of white noise just by disabling the Control Room via the VST Connections/Studio window. (repeat: the VST Connections/Studio window, NOT by using the switch in the Mixer Control Room panel.) I don’t use Control Room because of this…
(Pretty common set-up here: Mac Pro with MOTU interface running Mountain Lion. Nothing out of the ordinary)