RME users: Is TotalMix FX a replacement for Control Rm?

Yes, I too use TotalMix and not Control Room, partly because I love the basic volume / dim integration with the interface, and partly cos I do a lot of work in Pro Tools and other DAWs as well as Cubase, which would all require different solutions otherwise. It takes a while to get your head around, but its very flexible and, for basic operation day to day, quick and easy combined with the hardware.