I’ve recently upgraded from N4 to N6 and my record latency on 48samples went from 2.56 ms in and 3ms out to 5.5ms out on the same hardware. That’s a round trip of 8ms! Constrain latency compensation just made it skip audio in the record file. I now can’t use my the control room for monetoring as I did with N4. I now have to put the Mic directly through on the rme total mixer. I have a new machine on the way and hope it will solve my latency issue I never had before.