+1
I use 64 bit Cubase and have a similar number of plugins. I disable all my 32 bit vst duplications and only run 32 bit plugins that work in JBridge. Most of the problems I had in the past were 32 bit plugs. When I was running Cubase 6 in 32 bit I had no end of issues with crashes related to running out of memory. A thing of the past now thank goodness.
nonlocal you did not say what system you are using and whether you are running a 32 or a 64 bit version of Cubase?