Hi, no deleting the inputs will not effect your vsti's or fx.
Some FX or VSTi's however can work with live input like Vocoders and comparable effects, when the input is deleted this functionality is broken then untill you re-apply the input settings.
Deleting outputs on the other hand do have effects (
you won't hear anything
Excuse me if I'm to simple, it is difficult to Judge someone's knowledge based on a few posts.
Win8.1, 3930K@3.2Ghz, 32GB, Cubase 8 pro & artist 8, wavelab 8 elements, HSO, RND Portico 5033, UR824+MR816X+Focusrite pro 26 IO, CC121, Cubase IC pro, Halion 5, VG2, Arturia Analog Lab, TRacks CS grand + all custom elements, BFD3, Amplitube 3, Z3TA+2, (fender, orange, SVX collections, slash), HSO library, Waves Gold, SSL, EKramer sign, API & SCHEPPS bundle, NI Komplete 10 Ultimate, Fender Jazz basses, tube amps and 12 inchers