Your input latency looks massive at 40ms you will notice a lag when playing virtual instruments.
Otherwise the set up looks ok.
Make sure it’s Focusrite asio driver you are using.
Go to control panel on focusrite to check its set to internal sync.
See if it works ok with Media player if all else fails.
I had problems with my Focusrite 18i6 and needed the beta driver to fix it.
Also it wont like being plugged into a usb3 connection or a Hub.
Plug into direct usb2 from Pc.
Anything else sharing the same usb in out can slow it down i.e external hard drive.
Allways worth running scan disk from bootup to see if that helps.
Mike001