UR22 not working when linking multiple usb cables

You’re really pushing it! As a USB 2 device (will work on a USB 3 port though), the maximum cable length stipulated by the USB 2 standard is 5 meters or about 16 feet. The UR interface is signal-time critical and must be connected directly to a primary USB port on the computer (i.e. cannot be run over a hub). With a USB2 type audio interface, the shorter the cable the better, and pushing the cable length to the limit is only asking for trouble - if indeed it works at all (which, it would appear by your endeavours, it does not).
I’m sorry to say - but you’re SOL in this regard.