Try almost doubling (1.83) the distance away from your 22", and see if you still think you can read it easily enough, and be able to accurately click the mouse.
In what way? Cubase is a desktop program and does not scale at all (that is, a button will always have the same pixel dimensions), but just can show more info if there are more pixels. Text and lines in Cubase will be the clearest if you use the native resolution.
Screen display height will be just a tiny bit larger than your 22", and a 1/3 wider.
A 4K will be equivalent to three of them.