Cubase 8 .cpr file association

Oh, sorry, I didn’t get you tried that already (and didn’t check the MS video which requires Silverlight, BTW :wink: ).
That is weird, especially if you are using an admin profile.

If both that and trying to associate the files extension in ‘Programs → Default Programs → Set Association’ didn’t work, I’m afraid you are right in thinking it might need a registry manual fix (can’t really remember where this stuff is on top of my head, sorry). But I’d think uninstalling and re-installing Cubase (the application only, not the plug-ins, extensions and Content) might be faster - that should also re-assign the cpr extension to Cubase.