Hi, no deleting the inputs will not effect your vsti’s or fx.
Some FX or VSTi’s however can work with live input like Vocoders and comparable effects, when the input is deleted this functionality is broken then untill you re-apply the input settings.
Deleting outputs on the other hand do have effects ( 
you won’t hear anything 
).
Excuse me if I’m to simple, it is difficult to Judge someone’s knowledge based on a few posts.