uninstall YS_USB driver 1.10.1v on pc (UR22mk11). RESTART computer, and give it time to finish with background services running (5min). REinstall USB hardware interface. next start or open cubase 9.5.3v go to STUDIO on top of menu and select Studio SETUP. click on VST Audio System and select yamaha Steinberg USB ASIO from choices on drop down box. click apply if not grey color and Finish by Clicking OK. done : )