UR22mkII problem with Mac OS 10.14.3

Thanks you for your answer, Ed. I’ve installed the Mac OS 10.14.4, the latest driver 1.10.5 but, still not working…
I have to unplug the usb cable from the audio interface and then plug it back in. So far, it’s the only way that I found to make my system work. Not very practical, I confess…