In my experience (mac to mac) Syslink is great with a couple of caveats. Some sound cards don’t fair so well as others. I had trouble going via ADAT from MOTU 2408 to 828. Since replacing 828 with RME via MADI and ADAT, problems gone.
My setup is a composition based one - running a whole film on a slave Nuendo, and loading/creating cues on master Nuendo. So the slave Nuendo (which could as easily be Cubase) acts as a grand multitrack tape deck with picture sync.
I still favour MMC and MTC over Syslink for two reasons. 1st, with Syslink the slave “copies” my LR locators on the master which I don’t want. So if I change the L locator position. On one machine the other copies. Also cycle mode copies too. Finally, with MMC you can arm tracks and run reversed LR locators on master (to experiment with skipping bars etc while composing) and have the slave play straight.
Syslink is damn fast to lock up, but too inflexible for me.
Both methods should work independently of platform.
B