I can’t speak for the S3 or Nuendo, but my Nucleus 2 doesn’t play well with Cubase 9.5 Pro. The default Cubase/Nuendo profile doesn’t do what it says on the tin. I can’t make head nor tail of it really.
I edited the default profile and managed to get it to at least open a VSTi window but that was it. COuldn’t manage to edit any of its parameters.
I can change insert FX but not edit the parameters.
The scribble strips are all laid out in a weird way.
I gave up at that point. Not at all intuitive, which is what a control surface needs to be.
It’s seamless with Logic Pro. Totally opposite experience. everything works. Everything is on a knob or fader. All plugin params come up on VPots, and the scribble strips are excellent.
Sorry I can’t be of more help