UR22mkII on all the time?

There are 2 things that make electronics suffer the most:

  1. Temperature changes while operating and in particular overheating.
  2. Switching off/on. Which automatically is related to (1) because it needs to warm up.

So if you can keep your unit switched on and can keep it on optimum operating temperatures theoretically your device will live longer than switching it off/on all the time.