If you were to build a new audio computer today - what would you choose?

It’d be better if people knew what your “usual host of plugins and VSTi’s” were.

Since your question is “what would you choose”, and “you” is me, my answer is I’d choose a Ryzen 7 2700x based build with 16GB of 3200MHz memory minimum. I would do that because;

a) it’s sufficient processing power for my mixing needs now
b) it’s a good price/performance ratio
c) on that note it includes a cooler, and like you I already have a dedicated GPU
d) I hate Intel
e) 8 cores will be better in many cases other than DAW use, such as some video processing and multitasking

That said you are obviously not me, so…