Bring down your buffer size (ie 96 damper in RME settings panel).
This only works ok when using plugins that don’t introduce much latency themselves (multiband processors etc.) and whatever you do, there’s still some latency left. It can be close to unnoticeable small in projects that don’t already use much resources. Adding more and more plugins will lead to crackles and the like until you increase buffer size > get more delay again…