WaveLab LE 8 64 bit won't run in Windows 10

No idea what the problem is, but this says it should work:
https://www.steinberg.net/nc/en/support/knowledgebase_new/show_details/kb_show/product-compatibility-info-regarding-microsoft-windows-10.html
Have you tried re-installing Wavelab LE, or are you using an 8 version before 8.0.4?