Hello Marcus,
thank you for showing up. The forum thread at rme is Serious rme + Cubase 6 ASIO issue (Page 1) — HDSP(e) series — RME User Forum.
However, the answer I received was through email:
I’m afraid I have no explanation, but would assume it is a Cubase issue, not an RME one. Changing latency resets the driver, so this should help.Have you contacted Steinberg?
Regards, Daniel Fuchs, RME