Unfortunately the whole workspace area in Nuendo and Cubase is quite buggy. For example sometimes the same default project is loaded with slight differences. The more monitors and the problem gets worse. On my other, smaller workplace I have a single 30" Cinema display and it works better.
What me annoys totally is the fact that saved Workspaces are never recalled correctly, no matter what, when I transfer e.g. a Cubase project from my smaller workplace to the other. Recalling a Workspace doesn’t load the correct mixer setting, including zoom settings, and connections at all. Manually I have to edit every time the mixer settings (visibility of channels, racks etc.), the connections of the I/O (have to restart Nuendo/Cubase, execute a script to reestablish the I/Os) and some other details. A total recall concept which isn’t total recall but a partial, manual recall. This situation is for years like this (I reported it) - nobody seems to care about the mess - makes me upset.