Noises & Glitches On Save

I run CB 7.0.6 since it was released, with no problems.

Although I have not altered any hardware, the last couple of days when a project is on play back and (as usually) I press FILE/SAVE I get a terrible grzzzz noise.

If the project is on stop mode and I press save, no noise is present.

added…
The situation is getting worst. I hear crackles even on play back. Unfortunately this happens only in CB, not in any other sound programs.

I re-install the sound card, optimized the PC for sound performance, tweaked the buffers size, etc but still nothing.

Any ideas or help will be appreciated.

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Cubase 7.0.6, Win 7 Professional, Version 6.1.7601 SP 1, Intel Core i5-3450 CPU @ 3.10GHz, RAM 8.00 GB