More food for thought, and potential ways to reproduce the issue: FYI: software conflict/avast free & Yamaha UR22 driver - Computer Setup and System Configuration Forum - KVR Audio
I recently installed Avast free (windows 10). I then noticed audio dropouts when using my UR22 for guitar input. I just uninstalled Avast and all is back to normal
I have Avast Free installed too btw. On my desktop machine, which had the drop out issues (which i then solved by deactivating the wireless card, as i wrote above), and on my laptop, which doesn’t have issues. For what it’s worth.