Indeed. That’s precisely how the above-mentioned Mus2 works but Mus2 has its own internal playback synth. For midi instruments and softsynths it’s a bit complicated; that’s how I write Johnston’s notation in Finale, by first defining the tuning of the white notes using a re-tunable sound module (with .scl files, .tun files etc), and then defining pitch bend values for the accidental symbols.