I never heard of Cubase safe mode. I did a search and found out you need to hit Ctl, alt and shfit.
Bare in mind I deleted my preferences initially and it got me into Cubase 9.5. However once my preferences were saved, I started having problems again.
Your suggestion worked as I am now in Cubase 9.5. Thank you. 
That’s the good news. I hope Steinberg can find a way to correct this issue. Its annoying to setup my Mackie Controller presets as well as BFD3 drums every time I open Cubase. This issue I don’t have with version 8.5 so there must be something different they did with the programing of the latest version.