I do agree, the Panorama is the best choice for me (P1 here) with Cubase and Reason, there is still more “out of the box” control and integration than with any other controller.
I have hopes that Nektar will continue to improve on an already great mix controller, but am very impressed with this as it is currently.
I recently got S1 3.5, and have only the basic midi controller integration with that → after assigning everything/controllers from S1, then saving as an S1 template. I wish PreSonus would work with Nektar to improve this, it would be awesome if it could work as well as Cubase and Reason does with the P1/P4/P6.