This is particularly tough in cubase. The closest I’ve come is a combination of group buses with mix converts or mix 6to2 plugins. I had a sample project for reaktor here Cubase: Possible to have both Audio in AND multiple outputs? | NI Community Forum
working on vcv rack but it is tough because you have to nail the routing the first time or the vcv bridge stops operating. I think it’s not being released by the host.