There are several posts, with long lists of system configuration settings (some for UEFI, others for Windows 10) to customise yoyr system for Cubase, but they’re only useful if you need your computer just for Cubase and nothing else.
On a 10-core i9, I get spikes and dropouts even with a single track project (which I used only for testing). My system features 32GB Ram, m.2 ssd, 4x nvidia gpus (for 3d rendering), 5x Sata HDDs and a Thunderbolt card, on an Asus X299 Sage Workstation motherboard.
Looks like Windows 10 is not good at managing resources efficiently, or Cubase doesn’t make good use of the operating system’s capabilities, or both are true. Can’t be sure…