Hyperthreading should be On.
If that somehow decreases performance, then something somewhere is wrong.
Unfortunately, it’s not so simple. It depends on what you understand for “better performance”. If you disable Hyperthreading you give more time to the different cores to synchronize their threads, so it’s very likely that you get better ASIO performance (less clicks) at very low latencies, especially when playing VST instruments. However, if you’re at the mixing stage and higher latencies aren’t a problem, then yes, Hyperthreading can give you a boost in performance, usually no more than 20% in my experience.