I do rock (with just some VST instruments but quite a lot of effects on audio tracks - I tend to have whole albums as one project with about hour in length and around 150 channels), Electronic (With 97% VSTi’s) and orchestral with big sample libraries. I have the buffer set to 64 samples by default but raise it to 128 or 256 when mixing.
I tend to use 88,2kHz with 32 bit float.