Yes, I noticed the multiple calls on the e-licenser and I think this is normal. If the app is open you can see the calls going through. However I didn’t find it made any difference to the actual errors occurring, if the app was open or not.
These seem to help:
Having a newish dongle
Mount the dongle on one of the computer’s USB busses, not a hub
However I did all these and still got errors, the only thing that fixed it for me was the 32 bit E-licenser app.