I think you can work with 22 050 Hz audio file but
better still work with 44 100 Hz audio file and as Arjan say’s above
then use Crystal Resample / Render to 22 050 Hz finale audio file
then when playback this 22 050 Hz file insert Crystal Resampler plug-in at 44 100 Hz
then there should not be any pitch or speed problems
keep in mind to Resample when needed to support your Audio Device
with odd sample frequences
regards S-EH